In this study, it was found that the expression levels of Wnt and β-catenin in MSCs were obviously downregulated after treating with the exosomes of multiple myeloma cells and LINC00461-expressed vectors, suggesting that LINC00461 regulates the osteoblast differentiation of MSCs via inactivating the Wnt/β-catenin pathway. Here, MIR9-2HG is linked to AL amyloidosis.