As we move into our third decade of developing HER2 therapy at a time where tumor agnostic treatment approaches and NGS testing in metastatic cancer is common, utilizing ERBB2 CNG by NGS to identify patients for clinical trials evaluating novel HER2 therapies in new disease settings may be a more efficient screening strategy, and has been employed in the MyPathway (NCT 02091141) and NCI-MATCH (NCT 02465060) trials successfully. This evidence concerns the gene ERBB2 and metastatic malignant neoplasm.