Moreover, changing the subcellular localization of SPHK1 had a significant impact on cell function, with cell membrane-translocated exhibiting an effective inhibitory effect on the G1-S phase transition of 3T3-L1 fibroblasts, indicating that the localization of SPHK1 in cells may play a crucial role in the apoptosis of tumor cells [17]. Here, SPHK1 is linked to neoplasm.