Our study finds that the mRNA expression levels of IL-6, ICAM, and TNF-α were always high in the diabetes group during the 10-week observation period, and the high expression levels began to appear on the 8th day after the DM induction, but the mRNA expression level of CD18 began to increase significantly at the 4th week after induction, and reached the peak at the 6th week. This evidence concerns the gene IL6 and diabetes mellitus.