Meanwhile, Ewing sarcoma breakpoint region 1 (EWSR1) - E26 transformation-specific (ETS) fusion gene is the major factor (85% of cases are EWSR1-FLI1, and 10% of cases are EWSR1-ERG), and EWS-ETS may promote tumor metastasis and invasion by altering RNA transcriptional regulation and epigenetic modification [11, 12]. Here, EWSR1 is linked to neoplasm.