NLRP3 and hyperlipidemia: In addition, we also report that Zhilong Huoxue Tongyu capsule can improve the metabolism of serum lipids and reduce the formation of carotid atherosclerotic plaques in hyperlipidemia and carotid atherosclerosis rabbits, which may be associated with the inhibition of NLRP3 inflammasome activation and downstream inflammatory factors release by suppressing the phosphorylation of NF-κB. Thus, we concluded that Zhilong Huoxue Tongyu capsule exhibited the antiatherosclerosis effect through NLRP3 inflammasome signaling pathway [20].