AKT1 and Cowden disease: Further observation of the role of the LKB1-mTOR-PI3KC signal transduction network in CD autophagy and the regulatory effect of herb-partitioned moxibustion showed that PI3K, AKT1, and LKB1 mRNAs in CD rat colon tissues were significantly higher than those in the normal group, and mTOR protein was significantly lower than that in the normal group, indicating that key upstream factors of mTOR, including PI3K, AKT1, and LKB1, in the LKB1-mTOR-PI3KC signal transduction network are all activated in CD colon tissues, which could inhibit the expression of mTOR.