In summary, herb-partitioned moxibustion can significantly inhibit excessively activated autophagy in CD rat colon tissues, regulate the LKB1-mTOR-PI3KC signal transduction network, and downregulate the immune-related factors IL-1β, IL-17, and TNF-β, thereby alleviating and inhibiting intestinal inflammation in CD rats. Here, IL1B is linked to gastroenteritis.