As mentioned above, disruption of the dynamic balance between CD4+T cells is involved in the pathogenesis of colitis, and it is noteworthy that in patients with UC, Th17 cells are enriched and Tregs are scarce, and it has been well documented that the balance between Th17 cells and Tregs can be a potential regulatory target for improvement in colitis models [48, 49]. The gene discussed is CD4; the disease is colitis.