TGFB1 and hepatocellular carcinoma: Exposure to IL-6/IL-10/PGE2/VEGF/TGF-β or costimulatory inhibitory pathways can induce the increased proportion of tolerogenic DCs and the apoptosis of alloreactive T cells, and the abovementioned cytokines are expressed in the progression of HCC involving exosomes (especially TGF-β and IL-10) [133].