In addition, DEX containing alpha-fetoprotein (AFP) can stimulate mice with HCC to produce more IFN-γ and IL-2, which was conducted by the increase of CD8+ T cells and then decreased the regulatory T cells (Tregs), IL-10, and TGF-β, improving the tumor microenvironment [131]. The gene discussed is IFNG; the disease is hepatocellular carcinoma.