EDN1 and Cirrhosis: miR-155 and -199, while not observed in our studies, were implicated in studies of rat liver cells and endothelial cells in humans in response to chronic alcohol insult, and lead to inflammation in cirrhosis through endothelin-1 (ET-1) and hypoxia-inducible factor-1α (HIF-1α) (Yeligar et al., 2009).