TP53 and alcohol abuse: Given that alcohol abuse elevates the risk of many cancers (Fidler, 2003; International Agency for Research on Cancer, 2010; Wong et al., 2011; Zakhari et al., 2011; Miranda, 2014), it seems plausible that the dysregulation of miR-10a in alcohol abusers likewise leads to dysregulation of the p53 network in AUD individuals, underscoring how alcohol may act to elevate cancer risk.