Survival analysis of SCN4A and SCN7A in HCC by means of the Kaplan–Meier plotter showed that high SCN4A mRNA expression was correlated with better OS (HR = 0.5, 95% CI: 0.35-0.72, and p < 0.001), DSS (HR = 0.55, 95% CI: 0.35-0.86, and p = 0.007) and PFS (HR = 0.67, 95% CI: 0.49-0.92, and p = 0.012) (Supplementary Figure S2A), while high expression of SCN7A mRNA was associated with better OS (HR = 0.63, 95% CI: 0.42-0.93, and p = 0.018) (Supplementary Figure S2B). This evidence concerns the gene SCN4A and hepatocellular carcinoma.