TLR7 and Behcet disease: Fang et al. (2015) uncovered that more than 98% of people tested have two copies of all TLRs except for TLR7. In addition, they found that compared to healthy controls, male BD patients had an increased frequency of more than one copy of TLR7, and female BD patients had an increased frequency of more than two copies of this gene. This research suggested that a high TLR7 copy number may contribute to the pathogenesis of BD (Fang et al., 2015). Therefore, from this research, we included that TLRs also play a potential role in BD, and the mechanism underlying this still needs to be clarified.