Although Pontikos et al. (2014) did not find a relation of KIR3DL1/3DS1 copy number to T1DM in the white European population, Grayson et al. (2010) utilized a more powerful genome-wide CNV analysis and found 39 CNVs either enriched or depleted in T1DM patients, including a deletion on chromosome 6p21, near an HLA-DQ allele. Here, KIR3DL1 is linked to type 1 diabetes mellitus.