Interestingly, AUST2 genomic alterations and mutations result in intellectual disabilities and microcephaly; while KIAA2022 deficiency also produces intellectual disabilities, which have been related with impaired neurite outgrowth in rat hippocampal neurons (Van Maldergem et al., 2013; Beunders et al., 2016). This evidence concerns the gene NEXMIF and Intellectual disability.