In contrast, Pelleri et al. identified four ncRNAs (the DSCAM-AS1, DSCAM-IT1, and LINC00323 lncRNAs; and the MIR3197 miRNA) in their proposed DS-CHD region on Hsa21 (Pelleri et al., 2017) (Figure 1). This evidence concerns the gene DSCAM and coronary artery disorder.