ITGB4 and colorectal cancer: Pursuing predictors of colorectal cancer, a growing number of studies have identified valuable biomarkers, such as Integrin beta-4 (ITGB4) (Li et al., 2019), Placenta-specific protein 1 (PLAC1) (Ren et al., 2020), some miRNAs and lncRNAs(Hibner et al., 2018; Dastmalchi et al., 2020).