All-trans retinoic acid (ATRA) is an active metabolite of vitamin A, which is associated with increased ORMDL3 and shows protective effects on asthma, including maintaining airway epithelial integrity, inhibiting asthma effector cell differentiation, modulating immune response, etc. (Day et al., 2006; Zhuang et al., 2013; Garcia-Sanchez et al., 2016). This evidence concerns the gene ORMDL3 and asthma.