The pooled OR of heterozygote model was 1.35 (GA vs. GG, OR = 1.35, 95% CI: 1.04–1.77, p = 0.02), indicating that the risk of COPD with TNF-α-308 GA genotype was 1.35 times higher than that with the GG genotype in an Asian population. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.