For example, increased levels of Alu dsRNAs are seen in inflammatory diseases, MS (12), IBD (this study), SLE (49) in response to severe viral disease (10), and in certain forms of macular degeneration (31), and may be major drivers of the IRF and NF-kB driven transcriptional responses that are observed in these diseases and are thought to contribute to pathogenesis. Here, TRIM63 is linked to systemic lupus erythematosus.