The approximate curves, drawn from the results in the subjects classified according to the maximum severity of COVID-19, are shown in Figure 2, and those of the ratios of IgM(S1) to IgM(N) (IgM(S1/N)), IgM(RBD) to IgM(N) (IgM(RBD/N)), IgM(RBD) to IgM(S1) (IgM(RBD/S1)), IgG(S1) to IgG(N) (IgG(S1/N)), IgG(RBD) to IgG(N) (IgG(RBD/N)), IgG(RBD) to IgG(S1) (IgG(RBD/S1)), IgA(S1) to IgA(N) (IgA(S1/N)), IgA(RBD) to IgA(N) (IgA(RBD/N)), and IgA(RBD) to IgA(S1) (IgA(RBD/S1)) are shown in Supplemental Figure S1. The gene discussed is CD40LG; the disease is COVID-19.