Furthermore, it was shown that the mice with enforced expression of β-catenin in invariant natural killer T (iNKT) cell precursors presented particularly exacerbated lung inflammation when treated with IL-25 (54) and IL-17RB was able to induce β-catenin up-regulation thereby promoting lung cancer metastasis (33), indicating a potential regulatory role between IL-25, IL-17RB and β-catenin. The gene discussed is IL25; the disease is lung carcinoma.