Additionally, it was reported that genetic variations of IL-25 and IL-17RB was associated with type 1 diabetes mellitus (T1DM) (24); IL-25 had a function in improving glucose tolerance and stabilizing glucose homeostasis by inducing a series of cells to infiltrate into visceral adipose tissue, including eosinophils, NKT cells, innate lymphoid type 2 cells (ILC2) and alternatively activated macrophages (25). This evidence concerns the gene IL17RB and type 1 diabetes mellitus.