The proband presented initially with a long-standing history of treatment-refractory eosinophilic esophagitis (EoE) without preceding gastrointestinal tract fungal infections, and her mother was diagnosed with esophagitis as well.<h4>Conclusion</h4>EoE has been previously associated with alterations to STAT6 and STAT3 signaling pathways. The gene discussed is STAT6; the disease is esophagitis.