MEFV and familial Mediterranean fever: Whereas MEFV variants that are associated with FMF are gain-of-function variants, a subset of rare MEFV variants that result in defective binding to an inhibitory 14-3-3 protein cause a distinct autosomal dominant disease termed pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND), for which neurological involvement has not been reported (62, 63).