Arid5a is indispensable in the development of inflammatory and autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE) (15), sepsis (17), RA (26), acute lung injury (ALI) (27), as well as breast (20), lung (28), pancreatic (PDAC) (29), colorectal (CRC) (29), and brain (30) cancers. The gene discussed is ARID5A; the disease is cancer.