Alternatively, transcriptional activation Fosl2 and Arid5a inhibition by β-catenin in M2-like TAMs and partially regulation of macrophage gene expression by Tnf and Ccr2 results in the suppression of lung tumorigenesis and metastasis in lung cancer models developed using in vitro-trained TAMs and ex vivo-cultured TAMs isolated from mouse and human lung tumors (Figure 3B). This evidence concerns the gene ARID5A and lung carcinoma.