This ability imparts a dual function to Arid5a in the stabilization of mRNAs, including Il6 (15), Tbx21 (encodes Tbet) (17), Stat3 (16), and Ox40 (18), and in the transcription of genes, such as Pparγ (19) and lncRNA-AU020163 (20), some of which are associated with inflammation, autoimmunity, and cancer. Here, TBX21 is linked to cancer.