Arid5a is indispensable in the development of inflammatory and autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE) (15), sepsis (17), RA (26), acute lung injury (ALI) (27), as well as breast (20), lung (28), pancreatic (PDAC) (29), colorectal (CRC) (29), and brain (30) cancers. This evidence concerns the gene ARID5A and acute respiratory distress syndrome.