A central role of β-catenin-mediated Wnt signaling and transcription of fos-like antigen 2 (Fosl2) and Arid5a in the transition of tumor-inhibiting M1-like TAMs into tumor-promoting M2-like TAMs has recently been identified, which suggests a role for TAM-specific signaling in immune evasion in lung cancer (28) (Figure 3B). The gene discussed is ARID5A; the disease is lung cancer.