Transcriptome data revealed that Arid5a binds to the promoter region of Pparγ, which is the leading cause of adipogenesis, and represses the transcription of the Pparγ gene (Figure 1A), thereby inhibiting adipogenesis and obesity in mouse fibroblasts (19) (Figure 1B). This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.