Furthermore, in the nucleus of fibroblasts, Arid5a suppresses transcription of Pparγ, a master regulator of adipogenesis, thereby inhibiting adipogenesis and obesity in mice (19), whereas increased expression of long noncoding RNA (lncRNA)-AU021063 in breast cancer cells by binding to its promoter region resulted in the regulation of invasion and metastasis (20). Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.