We initially analyzed the transcriptional profiles of type I and III IFNs in jejunal enteroids after infection with SECoVs, and the results showed that the levels of type I IFNB1 and type III IFNs (IFN-L1 and IFN-L3) in enteroids were notably upregulated by TGEV infection, followed by PDCoV; whereas PEDV infection only induced a minor expression of type I and III IFNs (Figure 5A). Here, IFNL3 is linked to infection.