CALR and rheumatic disorder: tested serum samples from 144 patients with autoimmune rheumatic diseases and 121 individuals with nonautoimmune diseases using traditional double immunodiffusion and seven SPIA kits for rheumatic disease-related autoantibodies (U1-RNP, SS-A/Ro, SS-B/La, Sm, Jo-1, and Scl-70) (51).