Comparing Behcet’s disease patients with healthy controls, TLR1 and TLR2 were elevated in B-cells, TLR1, 2, and 4 were more highly expressed in both CD4+and CD8+ T-cells, granulocytes displayed a higher expression of TLR1, 2, 4, and 6, and the expressions of TLR2, 4, and 5 were significantly increased on classical monocytes (58). This evidence concerns the gene TLR1 and Behcet disease.