A large amount studies have shown that miRNA-548 suppresses tumor proliferate by binding WNT2 (90), murine double minute 2 (91), metastasis tumor-associated protein-2 (92), specificity protein 1 (93), cancerous inhibitor of protein phosphatase 2A (94), HMGB1 (95), and so on. Here, HMGB1 is linked to neoplasm.