cSiO2 also elicited extracellular granzyme B, which has been linked to lupus pathogenesis by cleaving autoantigens and exposing neoepitopes, as well as ACE and the aspartic acid protease renin 1, two key enzymes in the renin-angiotensin system. The gene discussed is GZMB; the disease is systemic lupus erythematosus.