For instance, inhibition of P2X4 receptor and 11β-hydroxysteroid dehydrogenase 1 was shown to attenuate activation of inflammasome NLRP1 and expression of IL-1β in both collagen-induced arthritis (CIA) model and synovial cells of patients with RA (61, 62). The gene discussed is NLRP1; the disease is rheumatoid arthritis.