For instance, the roles of PROS1-AXL (34), LAT-TNFRSF1B (35), ANXA1-FPR1 (36, 37), MIF-CD74 (38–40), SPP1-CD44 (41), VEGFB-VEGFR (42), IL6-IL6R (43), and OSM-OSMR (44) have been confirmed in macrophage activation in GBM. The gene discussed is CD44; the disease is glioblastoma.