Additionally, high FeAS GBM cells can also send signal to those cells by PROS signaling pathway (PROS1-AXL, Supplementary Figure 12C), LT signaling pathway (LTA-TNFRSF1B, Supplementary Figure 12D), ANNEXIN signaling pathway (ANXA1-FPR1, Supplementary Figure 12E) and MIF signaling pathway (MIF-(CD74+CXCR4), Supplementary Figure 12F). This evidence concerns the gene CXCR4 and glioblastoma.