Many studies implicate that the serum IL-18 levels of EC patients were significantly higher than the control group, deficiency of IL-18 can aggravate the progression and development of EC and IL-18 signaling is strongly associated with BE and EAC (Diakowska et al., 2006; Babar et al., 2012; Li et al., 2018). Here, IL18 is linked to Barrett esophagus.