In fact, accumulating evidence has suggested that the alterations in the production of several molecular coordinators caused by NAFLD may be detrimental to skeletal health, such as an excessive production of TNF-α (40), and deficiency of osteopontin (41), osteocalcin (42), and osteoprotegerin (43). The gene discussed is TNFRSF11B; the disease is metabolic dysfunction-associated steatotic liver disease.