PRNP and Alzheimer disease: We have recently described in 202/203 consecutive forensic autopsies of MMC 25.3 ± 9.2 years old, including 44 children, age 12.9 ± 4.9 years, the presence of neuropathological markers of Alzheimer's disease (AD): hyperphosphorylated tau (P-tau) and amyloid-β (Aβ) starting in 11-month-old babies (19), along with frontal cortex upregulation of gene clusters IL1, NFκB, TNF, IFN, and TLRs and downregulation of the prion-related protein [PrP(C)] (20).