GHRL and myocardial infarction: Notably, both one bolus and chronic administrations of ghrelin have been shown to ameliorate acute and chronic LV dysfunction and fibrotic remodeling of post myocardial infarction through potent sympathoinhibition and vagal activation (Schwenke et al., 2008a; Soeki et al., 2008; Mao et al., 2013b; Shirai et al., 2015).