INS and Insulin resistance: In addition, our group observed additional improvements using CT when compared to the strength and AT alone (Libardi et al., 2012), decreased low-grade subclinical inflammation and insulin resistance (Brunelli et al., 2015; Bonfante et al., 2017), interferes in concentrations of certain myokines (Brunelli et al., 2015; Bonfante et al., 2017), and improve global metabolome profile interfering in metabolic pathways related to glucose metabolism, insulin signaling and catecholamines biosynthesis (Duft et al., 2017).