Other factors that seem to influence the combination of these markers are the metabolic pattern, the presence of overweight, T2D, and insulin resistance, for example, which is associated with lower baseline concentration of some of these pro-thermogenic factors such as irisin or natriuretic peptides (Du et al., 2016; Verboven et al., 2017). The gene discussed is FNDC5; the disease is type 2 diabetes mellitus.