However, most of the information regarding the role of β-ARs in hypoxia-induced neovascularization originates from the fortuitous demonstration that the progression of infantile hemangiomas (IHs) is effectively reduced by a treatment with propranolol (an unselective β1-and β2-AR antagonist) (Léauté-Labrèze et al., 2008). This evidence concerns the gene CTBP1 and capillary hemangioma.