PRDX1 and systemic lupus erythematosus: In IMQ-induced psoriasis-like mice, sulforaphane reduced the proportions of Th1 and Th17 cells and induced the expression of the antioxidant gene Prdx1. Furthermore, our results demonstrated that sulforaphane increased the lifespan and reduced renal damage in lupus-prone MRL/lpr mice, decreased the proportions of plasma cells, Tfh cells, neutrophils, dendritic cells, and the concentration of MDA and induced the expression of antioxidant gene Prdx1.