Pu et al. (2021) found that Fisetin showed protective effects against ischemia-reperfusion injury through mediating the NLRP3 inflammasome pathway 34024736. Besides, former study confirmed that Fisetin reduced periodontitis by inhibiting inflammatory reaction via NLRP3 (Huang et al., 2021). What’s more, Fisetin has been found to reserve the TLR4/MD2-mediated activation of NLRP3 inflammasome in a p62-dependent manner (Huang et al., 2021) which is consistent with the findings of the present study. This evidence concerns the gene SQSTM1 and periodontitis.