The mechanism through which NLRP3 inflammasome causes DN is exceptionally complex, and LncRNAGm4419 has been implicated in glomerular thylakoid inflammation and fibrosis in hyperglycemic states via the NF-κB/NLRP3 inflammatory pathway, which ultimately results in the development of DN (Li et al., 2020). Here, NFKB1 is linked to liver dysplastic nodule.