The expression levels of NLRP3, caspase-1, apoptosis-associated speck-like protein, and IL-1 is-associated in patients with DN are considerably high, resulting in an inflammatory response in the body, which, in turn, leads to excessive production of ECM and various types of cell necrosis, and programmed cell death (Jo et al., 2016). Here, IL1B is linked to liver dysplastic nodule.