Overall, inflammatory cytokines lead to NF-κB signaling pathway activation, which can induce expression of matrix-degrading enzymes, such as matrix metalloproteinase (MMP) and C-reactive protein (CRP) 5, and increase erythrocyte sedimentation rate (ESR), which are involved in cartilage degeneration and osteoarthritis (Pennock et al., 2007; Sakkas and Platsoucas, 2007; Mohamadpour et al., 2013; Chen D. et al., 2017). Here, CRP is linked to osteoarthritis.