GPT and kidney injury: Bacterial pneumonia: treatment group (10%), control group (5%). SAEs: treatment group (24%), control group (21%). Circulatory shock: treatment group (10%); control group (5%); Acute kidney injury: treatment group (19%), control group (16%). ALT ≥3ULN: treatment group (24%), control group (16%). AST ≥3ULN: treatment group (29%), control group (21%)