Treatment with curcumin has been reported to inhibit the release of inflammatory cytokines, the expression of fibronectin, vimentin and TGF-β1, the hydroxyproline content, the ECM accumulation, the collagen I and IV deposition, the production of TNF-α, superoxide, NO and MDA as well as to raise the expression of SOD and GPX in bleomycin-induced pulmonary fibrosis murine models (Punithavathi et al., 2000; Zhou et al., 2006a; Zhou et al., 2006b; Zhang et al., 2007b; Xu et al., 2007; Chen et al., 2008; Zhao et al., 2008; Smith et al., 2010; Durairaj et al., 2020). This evidence concerns the gene TNF and pulmonary fibrosis.