In IPF patients, neutrophils show an increased expression of Nox2 subunits (Kato and Hecker, 2020) and genetic removal of some of these subunits partially protects from the development of fibrosis in lung fibrosis mice models (Manoury et al., 2005; Kato and Hecker, 2020). This evidence concerns the gene CYBB and pulmonary fibrosis.