Other pulmonary fibrosis models such as paraquat-, silica particles-, radiation-, aspiration material- and amiodarone-induced models have revealed that curcumin is able to reduce the levels of TGF-β1, TNF-α, IL-6 and collagen type I, and to decrease the generation of ROS, hydroxyproline content, MDA and MPO and iNOS activity, to increase the activity of SOD, GPx and HO-1 (Thresiamma et al., 1998; Punithavathi et al., 2003; Xu et al., 2007; Guzel et al., 2009; Jiang et al., 2009; Lee et al., 2010b; Cho et al., 2013; Li et al., 2015; Barsan et al., 2021). The gene discussed is HMOX1; the disease is pulmonary fibrosis.