For example, ILC2s, potent sources of IL-5, IL-9, IL-13, and PGD2, have been found to be higher in blood and sputum of severe asthmatics on high-dose steroids compared to mild asthmatics (Smith et al., 2016), and that these numbers are even higher in those with uncontrolled eosinophilia despite OCS. Here, IL5 is linked to Increased total eosinophil count.