IL1RL1 and asthma: In severe asthma, three transcriptome-associated clusters (TACs) have been identified, including TAC 1 (IL-33R, CCR3, TSLPR), TAC2 (interferon-, tumour necrosis factor alpha-, and inflammasome-associated genes), and TAC3 (genes of metabolic pathways, ubiquitination and mitochondrial function).