Although antihistamines (loratadine and cetirizine) and anti-inflammatory drugs (inhaled and topical steroids) remain the mainstay of treatment for allergic diseases (Kruse and Vanijcharoenkarn, 2018), side effects such as nasal irritation and epistaxis, lack of patients’ perceived effectiveness and high cost of biologic therapies targeting IgE (omalizumab) are challenges to the clinical management of allergic diseases (Kruse and Vanijcharoenkarn, 2018; Baiardini et al., 2019). This evidence concerns the gene IGHE and allergic disease.