CASP3 and cancer: Decreased cell growth on soft agar and decreased the invasive potential of cancer cells. Activated caspase-3, G0/G1 phase cell cycle arrest, and downregulated cyclins D1 and D3 and induction of p27. Decreased NF-κB DNA binding, reduced expression of p- IκBa, abrogated NF-κB activation, and downregulated NF-κB-regulated metastasis-promoting proteins