The 5-Lipoxygenase (5-LO) inhibitors AA-861, BWA4C, C06, CJ-13,610 and the FDA approved compound zileuton as well as the pan-LO inhibitor nordihydroguaiaretic acid (NDGA) (Figure 1) are frequently used to study the role of 5-LO and leukotrienes (LT) in models of inflammation, pain and cancer. This evidence concerns the gene ALOX5 and cancer.