Therefore, in the functional characteristics of CuS@BSA-NB2 nanoparticles, NB2 was used to establish the function of targeting and recognizing tumor cells with high expression of HER2, and CuS@BSA nanoparticles were used to exert photothermal effect to treat tumor cells to achieve the combined treatment program of photothermal therapy and targeted treatment. This evidence concerns the gene ERBB2 and neoplasm.