Phosphorylation of NFH is key for axonal transport, axonal caliber, axonal diameter, axonal plasticity, and neuronal morphology, and accumulation of neurofilaments as well as variations in modifications to neurofilaments like phosphorylation are present in neurodegenerative diseases such as PD (Nixon and Sihag, 1991; Pant and Veeranna, 1995; Kashiwagi et al., 2003; Liu et al., 2011; Kirkcaldie and Dwyer, 2017). The gene discussed is NEFH; the disease is Parkinson disease.