SENP3 and gastrointestinal disease: One of the top networks of the functional analysis involved five of the proteins with the biggest fold change, namely branched-chain alpha-keto acid dehydrogenase E1 component beta (BCKDHB), EEF1A2, MEPCE, prothymosin alpha (PTMA), and SENP3, and the diseases and disorders of cancer, organismal injury and abnormalities, and gastrointestinal disease (Figure 2E).