As well, the nuclear factor erythroid 2-related factor 2 (NFE2L2/NRF2)-mediated oxidative stress response and BAG family molecular chaperone regulator 2 (BAG2) signaling pathways have both been implicated in PD (Jazwa et al., 2011; Che et al., 2013; Qin et al., 2016; Todorovic et al., 2016) (Figure 2D). Here, BAG2 is linked to Parkinson disease.