The in vitro and in vivo evidence demonstrates that scutellarein and scutellarin can inhibit PF progression through regulation of the TGF-β/Smad, PI3K/Akt, Bax/Bcl2, or NF-κB/NLRP3 pathways (Miao et al., 2020; Peng et al., 2020). This evidence concerns the gene AKT1 and pemphigus foliaceus.