According to the results of the PPI network, the potential targets of WBT against PF included ALB, VEGFA, STAT3, MAPK1, MMPs, TGFB2 and its receptors, and FGF2 and its receptors, which participate in many progressions of PF, such as ECM deposition, EMT, and myofibroblast differentiation. This evidence concerns the gene MAPK1 and pemphigus foliaceus.