There are numerous members in the deubiquitinase family that are important components of the ubiquitin-proteasome pathway, and can participate in skin diseases such as psoriasis and skin squamous cell carcinoma by interacting with ectodysplasin receptor, Fas-associated death domain protein, B cell-stimulating factor-3, nuclear factor kappa-B protein kinase inhibitor, and other factors (Zilberman-Rudenko et al., 2016). The gene discussed is CLCF1; the disease is skin squamous cell carcinoma.