By testing pseudotyped viruses harboring the VSV-G, we found that some compounds, including fluoxetine, clomipramine, chlorpromazine, flupenthixol, pimozide, and reboxetine, counteract the infection in HEK-ACE2-TMPRSS2 cells suggesting that these drugs are not specific for SARS-CoV-2 spike protein. This evidence concerns the gene TMPRSS2 and infection.