RB1 and neoplasm: In an HPV-driven tumor, oncoproteins E6 and E7 are transcribed from the virus DNA and expressed in the tumor cells, leading to an interaction with growth regulatory proteins such as tumor suppressors TP53 (p53) and retinoblastoma (RB1), progression into the cell cycle, and acquisition of genomic instability (Münger et al., 2004; Doorbar et al., 2015).