In FL-HCC, a ∼400 kilobase deletion on chromosome 19 gives rise to the DnaJ Heat Shock Protein Family (HSP40) Member B1 (DNAJB1)-Protein Kinase CAMP-Activated Catalytic Subunit Alpha (PRKACA) fusion gene, and the corresponding DNAJB1-PRKACA-fusion protein has upregulated protein kinase activity to promote tumorigenesis (Honeyman et al., 2014). This evidence concerns the gene PRKACA and hepatocellular carcinoma.